Why Cancer Can’t Be Cured. Unless…
Acute stress is unique to man. The chart below reveals the amount of adrenal stress hormones (cortisol) released by humans compared to other animals.
There are exceptions: guinea pigs, fruit bats, primate monkeys. These four species share a genetic flaw. Unlike other mammals, these do not synthesize ascorbate from their liver (ascorbate being the medical term for vitamin C).
A liver enzyme (gulonolactone oxidase) required to produce vitamin C is missing in humans due to a defect in the GULO gene.
Animals that internally synthesize vitamin C handle stress naturally. Humans are unable to handle stress adequately because of the genetic flaw that impairs internal vitamin C production.
Animals that synthesize ascorbate are known to maintain blood plasma at saturation levels regardless of health challenges, dramatically increasing vitamin C-production internally in response to physical or emotional stress.
It was biochemist Irwin Stone in the 1970s-1980s who showed that humans have a genetic flaw that resulted in the inability to internally produce vitamin C as most other animals do.
Stone then noted the present-day requirement for vitamin C (60-200 milligrams/day) is at least 300 times less than the amount of vitamin C produced endogenously each day by other mammals. For example, an unstressed goat makes ~13,000 milligrams of vitamin C internally per 150-lbs of body weight.
Why humans don’t all have scurvy
Dietary intake of vitamin C is paltry compared to the internal synthesis humans experienced before this universal gene mutation affected all of humanity (110 mgs/day versus 1000s of mgs/continuously). One would think every human being would develop symptoms of scurvy – – fatigue, anemia, weak blood capillaries, hemorrhage, skin bruising, lassitude, painful joints, bleeding gums, shortness of breath, nausea.
Humans make up for their inborn vitamin C deficiency by recycling vitamin C. As vitamin C is exposed to oxygen in the blood circulation it is converted into an oxidized form called dehydroascorbate (DHA).
Dehydroascorbate is structurally similar to glucose and can be taken up into red blood cells. DHA within red blood cells then converts back to ascorbate vitamin C. This recirculation of DHA back to ascorbate is what spares every human from dying of scurvy, which is a frank vitamin C deficiency (below 11.4 micromole blood concentration).
More about stress and vitamin C
But let’s return to the subject of stress and vitamin C. It is no wonder ascorbate levels are the highest in the adrenal glands. It is where all the stress/survival hormones come from.
It is physical or emotional stress that activates the adrenal glands, located on top of the kidneys, to secrete stress hormones (called cortisol, adrenalin, epinephrine/ norepinephrine) that in turn release sugar stores in the form of glucose from the liver into the blood circulation. Said another way, stress induces high blood sugar levels.
Blood sugar & vitamin C
Experiments have repeatedly shown that humans subjected to mental or physical stress experience a rise in blood sugar levels. Modern medicine calls this diabetes, but in fact it could more accurately be called stress disease emanating from a lack of vitamin C.
It is categorically impossible for most mammals to develop diabetes/high blood sugar because blood glucose is converted to vitamin C.
But this stress/sugar relationship creates a more serious problem than elevated blood sugar. Physical or mental stress creates a breeding ground for the most dreaded of diseases – – cancer.
The Warburg Effect
It was Otto Warburg in the 1930s who observed that tumors take up enormous amounts of glucose. This became known as the Warburg Effect.
When doctors seek to confirm whether a mass revealed in a x-ray is cancerous or not they order a CAT-scan with injected radioactive sugar. The sugar goes right to the tumor and lights up the scan.
Because cancer cells voraciously utilize sugar for their growth, this scan accurately displays the size and shape of the tumor mass and sequential scans reveal growth or regression.
Cancer patients are often advised to curb their sugar consumption because cancer cells feed off of dietary sugar, sucrose (cane sugar) and fructose (corn sugar).
However, glucose is a sugar naturally produced in the liver that is an essential source of energy in all the cells of the human body. The human brain accounts for 2% of the body by weight but consumes 20% of glucose-derived energy (utilizes 5.6 milligrams of glucose per 100 grams of brain tissue per minute). The brain needs sugar to facilitate thinking capacity.
Low blood sugar may result in a person seeing spots before their eyes which is resolved with consumption of a sugar cube. So, there is no practical way to put a halt to glucose sugar so cancers won’t grow.
In one experiment cancer researchers, attempting to out-smart cancer, combined two medicines to induce a die off of cancer cells. The first drug was a beta blocker that blocks adrenalin secreted from the adrenal glands. The second drug was a sugar blocker (glycolysis inhibitor). The drug combo reduced tumor cell growth and induced tumor cell die off (apoptosis). But we still don’t have a cure for cancer.
Glucose gives tumor cells an advantage. Elevated sugar levels negate programmed cell death, a process called apoptosis (a-puhp-tow-suhs). Inhibit glucose and tumor cells are more likely to die off naturally. Glucose inhibitors (sugar blockers) are posed as the answer to this problem.
But there is still no cure for cancer because sugar in the form of glucose is still being pumped out of the liver, more so when a person hears the fear-evoking diagnosis of cancer!
If not sugar blockers, then maybe more vitamin C
So, if sugar cannot be blocked then maybe vitamin C intake can be increased to knock out cancer. Of course, modern medicine ridicules this idea. But doctors utilize sugar scans to diagnose cancer and cancer researchers experiment with sugar-blocking drugs to “cure cancer.”
Nay-sayers claim water-soluble vitamin C, with a half-life of 30 minutes, produces nothing but expensive urine. But Patrick Holford points out that consumption of 2500 milligrams of vitamin C per day more than triples blood plasma levels compared to “Recommended Daily Allowance” levels despite its rapid excretion.
Vitamin C provided to lab animals where tumor cells have been experimentally implanted experience a 4-fold delay in tumor growth compared to animals that do not secrete vitamin C internally. In one experiment, when laboratory mice that were genetically altered to nix internal vitamin C synthesis, tumor growth factors were reduced by more than two-fold. In the animal lab, even a moderate decrease in tissue ascorbate content, to levels still considered adequate for normal health, had a significant impact on tumor pathology.
When tumor cells are experimentally injected into animals that have been supplemented with vitamin C, tumor spread (metastasis) is reduced by 71% and growth factors by 98%, and tumor weight by 28%.
Nickel is a heavy metal. Exposure to nickel is associated with toxicity and cancer. Laboratory animals that have had their GULO gene incapacitated are 40% more likely to be susceptible to nickel-related cancer.
Vitamin C renaissance
Vitamin C therapy for cancer is undergoing a renaissance. The failure of modern medicine to discover a cure for cancer has caused researchers to revisit the vitamin C paradigm of cancer.
Cancer patients exhibit very low amounts of ascorbate (vitamin C).
The cancer cell-killing activity of vitamin C is attributed to transient production of hydrogen peroxide. According to a report published in Frontiers of Pharmacology, the administration of oral vitamin C achieves blood plasma concentration can reach 100-200 micromole whereas intravenous vitamin C achieves concentration as high as 15 millimole. (1 millimole = 1000 micromole)
Some reports claim only high concentration of vitamin C achieved by intravenous vitamin C administration have been demonstrated to kill cancer cells in a lab dish (and not kill off healthy cells).
When high blood plasma concentrations of vitamin C are maintained at 1 millimole or above, hydrogen peroxide (H2O2) is generated which selectively kills cancer cells and does not harm healthy cells.
A millimole (MIH-lih-mole) is the amount of a substance equal to a thousandth of a mole –a measure of the amount of a substance within a soluble base. Also called mmol.)
Mega-dose (20,000 to 50,000 milligrams) vitamin C administered orally or (100 grams) intravenously has been used to transiently induce hydrogen peroxide (H2O2) which selectively kills cancer cells and not healthy cells. H2O2 converts to H2O (water) which is totally harmless and non-toxic.
But the problem here is that intravenous infusions cannot easily be administered 24-hours a day for cancer patients without continual hospitalization. In between infusions of vitamin C the cancer cells roar back to life. (Chemotherapy has the same problem.)
However, in a lab dish anti-cancer effects have also been demonstrated with more modest concentrations of vitamin C (below 1 micromole and even 1 micromole).
Humans must obtain vitamin C totally from their diet, about 110 milligrams per day in America. Compare that to wild gorillas that consume 8000mg of vitamin C a day largely by eating bamboo.
Measures of blood levels of vitamin C in the US population reveal 13% of the population is vitamin C deficient (below 11.4 micromole/liter blood sample). The mean was 51.4 micromole with smokers exhibiting having a one-third lower level (38.6 micromole) than nonsmokers (2009 data).
The turnover (intake, transport, utilization, excretion) of vitamin C as a water-soluble nutrient is rapid and constant. It must be continually replaced. Most oral vitamin C is excreted within 30 minutes. The depletion of vitamin C is accelerated during illness, in particular in cases of cancer. There are anecdotal reports of cancer remissions among patients taking oral vitamin C, but these are not commonly seen.
In contrast, animals that synthesize ascorbate are known to maintain plasma saturation levels regardless of health challenges. In animals that have had their GULO gene experimentally disabled, it was possible for these animals to achieve the same blood concentra
Article from LewRockwell